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KMID : 0895820030130020011
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Journal of Oriental Rehabilitation Medicine
2003 Volume.13 No. 2 p.11 ~ p.29
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Effect of Rehmanniae Preparata on the Starvation Stress of the Mice
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Yoon Jong-Tae
Lim Hyung-Ho
Lee Tea-Hee
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Abstract
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Objectives: This study aimed to evaluate the effect of Rehmanniae Preparata on the stress induced by starvation on the change of the corticosterone, the rectal temperature and the contents of monoamines in the hypothalamus of mice.
Methods: The four groups of experimental animals were starved for 36 hours after being administrated Rehmanniae Preparata with four different doses. Rehmanniae Preparata was administered 6 times before starting starvation. The corticosterone, rectal temperature and the contents of monoamines were measured after 36.5 hours starvation stress.
Results: 1. The plasma corticosterone level was decreased statistically significantly (P<0.05) compared to control group in the group administrated 1.0g/kg of Rehmanniae Preparata. The level was increased statistically significantly(P<0.05) compared to control group in the group administrated 3.0g/kg of Rehmanniae Preparata.
2. The rectal temperature was increased compared to control group in the groups administrated 0.25 and 1.0g/kg of Rehmanniae Preparata. It was decreased compared to control group in the group administrated 0.5g/kg and 3.0g/kg of Rehmanniae Preparata.
3. The level of NE in the hypothalamus was increased in both control group and experimental groups, but there was no statistical significance.
4. The level of DA in the hypothalamus was increased compared to control group in the groups administrated 0.25, 0.5 and
1.0g/kg of Rehmanniae Preparata.
5. The level of DOPAC in the hypothalamus was decreased compared to normal group in the groups administrated 0.5, 1.0 and 3.0g/kg of Rehmanniae Preparata.
6. The level of 5-HT was increased statistically significantly(P<0.05) compared to control group in the group administrated 3.0g/kg of Rehmanniae Preparata.
7. The level of 5-HIAA was decreased compared to control group in the groups administrated 0.5 and 1.0g/kg of Rehmanniae Preparata. It was increased compared to control group in the group administrated 0.25 and 3.0g/kg of Rehmanniae Preparata.
Conclusion: This study shows that Rehmanniae Preparata is significantly effective on reducing the starvation stress generally, but if the dose of Rehmanniae Preparata is too high, it can increase the stress.
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KEYWORD
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Rehmanniae Preparata, starvation stress, corticosterone, rectal temperature, monoamines
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